2024 Volume 30 Issue 5 Pages 577-582
The amount of 1,5-anhydro-d-glucitol (1,5-AG) present in the human body is kept almost constant value. Although the biological role of 1,5-AG in humans has yet to be elucidated, several biological effects have been reported. The estimates have shown that most of the 1,5-AG is obtained from our daily foods in the case of adults. No reports has been available on 1,5-AG amount in human milk or infant formula, therefore, the current study aimed to develop a method for determination of 1,5-AG concentration in the milk by combination of chromatography and 1,5-AG-specific enzymes, and to measure 1,5-AG concentration in several types of milk. We found that the amount of 1,5-AG in human milk was 6.51 ± 2.22 µg/mL up to 1 week postpartum and 11.7 ± 3.40 µg/mL around 1 month postpartum. However, all infant formulas contained less than 0.5 µg/mL of 1,5-AG.
