Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
Original papers
Hyaluronidase-Inhibiting Polysaccharide Isolated and Purified from Hot Water Extract of Sporophyll of Undaria pinnatifida
Takuya KATSUBEYukikazu YAMASAKIMasatoshi IWAMOTOSyuichi OKA
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2003 Volume 9 Issue 1 Pages 25-29

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Abstract

Polysaccharide showing inhibitory activity against hyaluronidase, which is known to be related to inflammation and tumor metastasis, was purified from the sporophyll of Undaria pinnatifida by fractionated extraction and column chromatography. On the basis of chemical analyses, the purified compound was found to be a kind of sulfated polysaccharide. The molar ratio of sugars and sulfuric acid in the purified compound was estimated to be L-fucose : D-galactose : D-glucuronic acids : sulfuric acid1.0 : 1.0 : 0.04 : 5.2. The number-average molecular weight of the sulfated polysaccharide was estimated to be 63,000 by high-performance liquid chromatography. This polysaccharide inhibited hyaluronidase activity (IC5013.0 μg/ml) in a dose-dependent manner.

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© 2003 by Japanese Society for Food Science and Technology
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