Anti-obesity effects of two Korean whole wheat cultivars in high-fat diet-induced obese mice

Abstract

This study compared the anti-obesity effects of whole wheat extracts from ‘Shinmichal’ and ‘Saekeumkang’ in mice fed a high-fat diet to evaluate their potential benefits in obesity management. ‘Shinmichal’ and ‘Saekeumkang’ treatment groups showed significant reductions in body weight gain. Histological analysis revealed that ‘Shinmichal’ and ‘Saekeumkang’ reduced lipid accumulation in epididymal adipose and liver tissues, with significant decreases in levels of hepatic total cholesterol (TC) and triglycerides (TG). Both cultivars significantly improved serum levels of glucose, TC, TG, and lipoprotein. Additionally, both wheat varieties led to reductions in the atherosclerosis index and coronary risk factor, indicating a lower risk of cardiovascular problems. The ‘Shinmichal’ and ‘Saekeumkang’ Korean wheat cultivars exhibit significant anti-obesity effects, including reduced body weight gain, lipid accumulation, and improved blood biochemical parameters. Both wheat varieties may be effective dietary supplements for the prevention of obesity, underscoring the value of domestic wheat production in addressing health issues.