ブタ冠動脈モデルを用いた生体吸収性PLGAナノ粒子電着コーティングステントの有効性と安全性

抄録

Background: The enthusiastic use of currently marketed drug-eluting stents presents a serious safety issue because of the associated increased risk of potentially fatal late thrombosis. Nanoparticle (NP)-mediated drug delivery systems (DDS) are poised to transform the development of innovative therapeutic devices. Therefore, we hypothesized that a bioabsorbable polymeric NP-eluting stent could provide a more safe and efficient DDS.

Methods and Results: We report the first successful formulation of an NP-eluting stent using a novel cation electrodeposit coating technology. NPs encapsulated with FITC were taken up stably and efficiently by cultured vascular smooth muscle cells. In a porcine coronary artery, FITC was observed in neointimal and medial layers until 4 weeks after implantation. The magnitudes of stent-induced injury, inflammation, endothelial recovery, and neointima formation were comparable between control and NP-eluting stent groups.

Conclusions: Therefore, this NP-eluting stent is an efficient and safe NP-mediated DDS that holds promise as a platform for innovative nano-devices targeting cardiovascular disease.