Patient with Neuromyelitis Optica Spectrum Disorder Combined with Sjögren's Syndrome Relapse Free Following Tacrolimus Treatment

Xueping Zheng; Xu Zhang; Xuejun Liu; Wenfeng Mu; Wenru Yang; Youxin Liu; Ping Ge; Haifeng Li

doi:10.2169/internalmedicine.53.0814

CASE REPORTS

Patient with Neuromyelitis Optica Spectrum Disorder Combined with Sjögren's Syndrome Relapse Free Following Tacrolimus Treatment

Xueping Zheng, Xu Zhang, Xuejun Liu, Wenfeng Mu, Wenru Yang, Youxin Liu, Ping Ge, Haifeng Li

著者情報

キーワード: tacrolimus, neuromyelitis optica, neuromyelitis optica spectrum disorder, cyclophosphamide, Sjögren's syndrome

ジャーナルオープンアクセス

2014 年 53 巻 20 号 p. 2377-2380

DOI https://doi.org/10.2169/internalmedicine.53.0814

詳細

抄録

Abstract Tacrolimus, a novel immunosuppressant agent, has been widely used in organ transplantation and autoimmune diseases. We herein present a case of neuromyelitis optica spectrum disorder (NMOSD) combined with Sjögren's syndrome (SS) successfully treated with tacrolimus. This patient repeatedly presented with recurrent longitudinally extensive transverse myelitis. Her NMO-IgG and anti-SSA and anti-SSB antibodies were seropositive. Considering the frequency of relapses and severe disability, tacrolimus was initiated after failure of intravenous cyclophosphamide. Her status was steady for over 36 months after tacrolimus treatment. This report indicates that tacrolimus may be a potentially effective immunosuppressant for NMOSD with systemic autoimmune diseases.

責任著者(Corresponding author)

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