2014 年 41 巻 4 号 p. 518-523
Objective To investigate the relationship between visceral fat area (VFA) with the anthropometric and biochemical clinical parameters of lifestyle-related diseases, adipocytokines, inflammation and atherosclerosis in Japanese men and women.
Subjects and methods The correlation between VFA and the following parameters was evaluated in 94 healthy volunteers (48 men and 46 women): body weight, BMI, waist circumference, body composition, blood pressure, glucose homeostasis, insulin resistance, lipids, uric acid, liver enzymes, leptin, adiponectin, high sensitivity C-reactive protein (hsCRP) and the degree of atherosclerosis (mean intima-media thickness by carotid ultrasonography).
Results The mean age was 40.1 ± 9.6 years (42.0 ± 10.2 for men and 38.1 ± 8.6 for women) and the mean VFA was 47.4 ± 40.9 cm2 (70.5 ± 41.4 for men and 23.3 ± 22.3 for women). VFA was positively correlated with blood pressure, fasting glucose, HbA1c, insulin resistance, LDL-C, triglycerides, ALT, γGT and uric acid. A negative correlation was observed in HDL-C and adiponectin. Furthermore, hsCRP and carotid intima-media thickness showed a positive association with VFA.
Conclusion The present study shows that those with subclinical visceral fat accumulation have potential atherosclerotic risk even though they show no apparent clinical abnormalities.
