Mean Corpuscular Volume is Equivalent to γ-GTP as an Indicator of Alcohol Intake
2004 年 31 巻 4 号 p. 552-556
詳細
2004 年 31 巻 4 号 p. 552-556
Objective Although Gamma-glutamyl transpeptidase (γ-GTP) is known as an alcohol indicator, it does not parallel alcohol intake, especially in women. In addition, mean corpuscular volume (MCV) is not widely used as an indicator of alcohol intake. The purpose of this article is to determine the efficacy of MCV as an indicator of alcohol intake, and the cutoff value of MCV in the population consuming appropriate amount of alcohol.
Method (1) Total of 6, 989 subjects aged 30 to 69 years were recruited during our health check-up, and MCV and γ-GTP were compared between different Ethanol groups. (2) The cut-off values for MCV and γ-GTP corresponding to the appropriate Ethanol (150 g in men, and 100 g in women) were calculated using receiver operating characteristic curves. Ethanol is alcohol intake per week expressed in gram of ethanol.
Results (1) MCV elevated with the increase of Ethanol in both sex. γ-GTP in men increased parallel to Ethanol, but not in women. (2) The cut-off values for MCV and γ-GTP corre-sponding to the appropriate Ethanol were 92 fL and 40 IU/L in men, and 90 fL and 17 IU/L in women, respectively.
Conclusion (1) MCV is an indicator of alcohol intake in both sex, while γ-GTP is an indicator only in men. (2) MCV is equivalent to γ-GTP in terms of indicating the appropriate alcohol intake. Overall, MCV is equivalent to γ-GTP as an alcohol indicator of appropriate alcohol intake.
