Abstract
The effect of carbon tetrachloride (CCl4) on adenosine 3′-monophosphate (3′-AMP) content and 3′-AMP-forming enzyme activity in rat liver was examined. The levels of 3′-AMP and the total amounts of adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate were decreased by treatment with CCl4. The 3′-AMP-forming enzyme activity in CCl4-treated rat liver homogenate was ca. 4-fold higher than that of control. The enzyme activity in CCl4-treated mitochondria was ca. 50% of control values. These results suggest that the increase in the 3′-AMP-forming enzyme activity in the cytosol may be, at least partly, due to the leakage of the enzyme activity from mitochondria in acute hepatitis induced by CCl4.
