Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
Excretory Profile of 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) in Rat
Tatsuyuki KanamoriKenji TsujikawaYoshihito OhmaeYuko IwataHiroyuki InoueYoshio InouyeTohru Kishi
ジャーナル フリー

2003 年 49 巻 2 号 p. 166-169


The urinary and faecal metabolic profiles of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rat were investigated. Male Wistar rats were administrated 10 mg/kg of 2C-B hydrochloride orally, and the urine and faeces were collected 0-24 and 24-48 hr after administration. The samples were processed by liquid-liquid extraction, and the extracts analyzed by GC/MS, after derivatization. The major metabolite excreted into the urine was 5-O-desmethyl-N-acetyl-2C-B, comprising 13.2% of the administrated dose. Other metabolites detected in the urinary extracts were 2-O-desmethyl-N-acetyl-2C-B (5.8%), 2-O-desmethyl-2C-B (3.5%), carboxylic acid compound (1.9%), 5-O-desmethyl-2C-B (1.2%) and an alcoholic compound (0.8%). Only 0.2% of the administrated 2C-B was excreted into the urine in its original form. On the other hand, only 5-O-desmethyl-N-acetyl-2C-B and 2-O-desmethyl-N-acetyl-2C-B were detected in the faecal extracts. The major fraction of the urinary metabolites that contained a hydroxy group were recovered as conjugates.

© 2003 by The Pharmaceutical Society of Japan