Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
REGULAR ARTICLES
Endogenous Level and in Vitro Production of GHB in Blood from Healthy Humans, and the Interpretation of GHB Levels Detected in Antemortem Blood Samples
Noriaki ShimaAkihiro MikiTooru KamataMunehiro KatagiHitoshi Tsuchihashi
著者情報
ジャーナル フリー

2005 年 51 巻 2 号 p. 147-154

詳細
抄録
The endogenous level of γ-hydroxybutyric acid (GHB) and the in vitro production of GHB in blood from healthy humans have been investigated. The endogenous GHB concentrations in aseptically collected whole blood samples ranged from 5 to 10 ng/ml, which were far below the previously-reported “endogenous” levels . Also, the levels of in vitro GHB production during storage for 16 months at 4°C were lower than 0.4 μg/ml, which were much lower than those in postmortem samples previously reported. Based on the results of this investigation, the authors concluded that an interpretative cutoff of 1.0 μg/ml would be appropriate for differentiating exogenous from endogenous GHB, if only limited to in-life blood specimens that were collected aseptically, stored at 4°C or lower, examined within two weeks, and excludes the possibility of GHB aciduria.
著者関連情報
© 2005 by The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top