Oxidative Stress-Dependent Cellular Toxicity and Cytoprotection during Exposure to 9, 10-phenanthraquinone, a Component of Diesel Exhaust Particles

抄録

Quinones are ubiquitously present in the environment. This review summarizes the cellular toxicity of 9, 10-phenanthraquinone (9, 10-PQ), a component of diesel exhaust particles, and the cytoprotective mechanism of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) system against oxidative stress exerted by 9, 10-PQ.