抗糸状菌剤に関する研究(II) : 芳香族硫シアン化合物の抗菌機作

抄録

It was previously reported that aromatic thiocyano compounds had inhibitory activity to the iron enzyme such as cytochrome oxidase. Present investigations are on the catalase, one of the iron enzyme. Enzymatic activity was estimated from the rate of H₂O₂ decomposition by means of iodine method. The inhibitory activity of these compounds to the purified enzyme was increased by the addition of muscle juice or heat denatured protein solution and the U. V. absorption curve of the enzyme-inhibitor complex corresponded with that in the case of cyanide. From the above experiments, it was presumed that this kinds of compounds became to get a strong enzyme-inhibitory activity by contact with the heat denatured protein solution or muscle juice, to produce a water-soluble material which had the similar activity as CN^- to the hemin radical in catalase molecule.