抄録
The conversion of local anesthetics in human cerebro-spinal fluid was investigated in vitro and an improved method for analysis of the local anesthetics in cerebro-spinal fluid was proposed. When hexylcaine, procaine and tetracaine were incubated with cerebro-spinal fluid, ester bonds of the compounds were hydrolysed mainly due to the increase of pH of cerebro-spinal fluid on standing, while amide bonds of dibucaine, lidocaine and carbocaine were unchanged. In the analysis of local anesthetics in cerebro-spinal fluid, it is desirable to estimate the ultra-violet spectrum of the sample and to determine the aromatic carboxylic acid liberated, as well as the determination of the unchanged anesthetics.
