Gas Chromatographic Determination of a Micro Amount of Cyclamate by the Method of Trifluoroacetolysis of Cyclamate

Abstract

Trifluoroacetolysis was performed by heating sodium cyclamate in trifluoroacetic anhydride at 90° for 1 hr. The reaction proceeded quantitatively to form N-trifluoroacetyl cyclohexylamine. The reaction was successfully applied to gas chromatographic determination of a micro-amount of sodium cyclamate in the range of 0.025-5 mg.