Abstract
The activity of β-glucuronidase and β-galactosidase in the femur of rats was examined after single intraperitoneal administration of lead (10.0 mg/100 g) or cadmium (0.15 mg/100 g) acetate, and the following results were obtained. Bone β-glucuronidase and β-galactosidase activities increased significantly (p<0.01) 1 day after lead or cadmium administration compared with control rats, and these enzyme activities were significantly increased 7 days after lead or cadmium administration. Bone β-glucuronidase and β-galactosidase activities were slightly elevated by the administration of a mixture of lead and cadmium. These results suggest that lead or cadmium may cause metabolic disorder in the bone tissue of rats.
