衛生化学
Print ISSN : 0013-273X
ヒマ種子中に含まれるRicinの生理活性に関する研究(第3報)Ricinの末梢血管透過性亢進作用について
古謝 紀和持田 研秀吉田 稔
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ジャーナル フリー

1975 年 21 巻 6 号 p. 337-340

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Ricin, a highly toxic protein, showed not only a pyrogenic activity but also a strong hemorrhagic activity in rabbit skin. Its activity was due to increased permeability of the blood vessel and therefore, it was more clearly demonstrated with 0.5% solution of Trypan blue, and this permeability was characterized by a long latent period and duration. Ricin had no caseinolytic activity or esterase activity using N-benzoyl-L-arginine ethyl ester and N-acetyl-L-tyrosin ethyl ester as substrates. These results suggest that ricin has a powerful inflammatory effect, but it is not an "inflammatory protease".
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