抄録
Changes of some metabolite and enzyme activities concerned with hepatic glycogen metabolism in mice were investigated by the intraperitoneal injection of endotoxin extracted from Vibrio parahaemolyticus. A marked depletion of hepatic glycogen, a considerable increase in blood sugar and a remarkable increase in blood-lactic acid amount were observed in the poisond mice 1-3 hr postintoxication. There was an increase in the activities of hepatic phosphorylase and G-6-Pase at 1 hr postintoxication, but the latter activity decreased thereafter. Hyperglycemia of mice was found in proportion to the dose of endotoxin, but mice injected with a large quantity (40 mg/kg) of endotoxin showed evident hypoglycemia after 16 hr.
