二塩化ビフェニルおよび十塩化ビフェニルのラットにおける体内分布ならびに排泄

抄録

After a single oral administration of p, p'-dichlorobiphenyl (Cl₂-BP) or decachlorobiphenyl (Cl₁₀-BP) to male rate the distribution of each chlorinated biphenyl in several organs and tissues of these rats and excretion of each compound into urine and feces were investigated. Only a part of Cl₂-BP and Cl₁₀-BP administered to rats was absorbed through the gastrointestinal tract, and a small amount of each compound was excreted into urine, but most of both compounds were excreted into feces. Both chlorinated biphenyls were very quickly distributed in all rat tissues, especially in hypodermic adipose tissue and skin, and later, both compounds were very slowly excreted into urine. The biological half lives of Cl₂-BP and Cl₁₀-BP in the rat tissues were found in the range of 5.5 hr in lung to 26.4 hr in hypodermic adipose, and in the range of 83 hr in the liver to 513 hr in hypodermic adipose tissue. It was indicated that Cl₁₀-BC was retained for a longer period than Cl₂-BP in the rat tissues and it was suggested that the metabolism and excretion of Cl₁₀-BP in rat were extremely slower than those of Cl₂-BP.