大麻成分, テトラヒドロカンナビノール, カンナビジオール及び活性代謝物とシンナー及びその含有成分との相互作用

抄録

The interaction of cannabinoids, tetrahydrocannabinol (THC), cannabidiol (CBD) and some active metabolites with thinner and its components was studied in mice and the following results were obtained. 1) Δ⁹-THC but not CBD (5 mg/kg, i.v.) significantly prolonged thinner-induced anesthesia by 1.8 fold. The latent period to induce the anesthesia was significantly shortened by Δ⁹-THC. 2) 11-Hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC (5 mg/kg, i.v.), which are active metabolites of Δ⁸-THC, significantly prolonged thinner-induced anesthesia by 2.0 and 3.2 fold, respectively. 11-Oxo-Δ⁸-THC significantly shortened latent period to induce the anesthesia. 3) Among cannabinoids examined, only 11-hydroxy-Δ⁸-THC significantly prolonged toluene-induced anesthesia by 2.4 fold. Thinner contains about 60% of toluene and a small amount of ethyl acetate, ethylether and ethylalcohol. 4) Δ⁸-THC and its active metabolites, 11-hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC significantly prolonged ethyl acetate-induced anesthesia by 4.4, 4.9 and 5.1 fold, respectively. Moreover, Δ⁸-THC, 11-hydroxy-Δ⁸-THC and 11-oxo-Δ⁸-THC significantly shortened latent period to induce anesthesia.