化粧品原料の生化学的研究(第1報)チロシナーゼ阻害作用

抄録

Tyrosinase inhibitory action (TIA) of cosmetic raw materials containing cosmetic whitening ingredients was measured as an in vitro screening procedure. Among them, L-ascorbic acid phosphate magnesium salt (VC-PMg) had no TIA. The decomposition of VC-PMg was also examined by acid-phosphatase (Acp), a skin enzyme. Consequently, VC-PMg was hydrolyzed to L-ascorbic acid by pseudo first order reaction. The reaction solution containing L-ascorbic acid had TIA. The whitening effects of several cosmetic raw materials could be compared by the in vitro TIA test.