抄録
Total inhalation deposition of direct-acting mutagenicity associated with environmental tobacco smoke (ETS) aerosol was measured in a human volunteer. The exposures were conducted in a normal office containing well circulated ETS. The ETS aerosol was collected by filtration in the exhaled air using the Hans Rudolph mask connected to a filter holder and respirometer. The inhaled indoor air was collected by low volume air sampler. The direct-acting mutagenicity of the aerosol was determined using the ultramicrosuspension forward mutation assay in Salmonella typhimurium strain TM677. The deposition ratio was estimated as ca. 55% from the difference of the mutagenicity between exhaled and inhaled air.
