Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
ショウジョウバエによる変異原検出試験
河井 一明
著者情報
ジャーナル フリー

1999 年 45 巻 1 号 p. 28-36

詳細
抄録

Since early 1980s Drosophila melanogaster larvae heterozygous for recessive visible markers and those with defective DNA repair capability have been intensively used as simple in vivo testers of mutagenicity of environmental agents. In pallalel with this activity, the somatic tests have recently been deployed as tools for the detection of modifiers of the mutagenicity and understanding of basic mechanisms of the effects. Here, I characterize the somatic systems in relation to the biotransforming ability of promutagens and the outcomes from the mutagenicity tests and review some aspects of the deployment.

著者関連情報
© 社団法人 日本薬学会
前の記事 次の記事
feedback
Top