抄録
Angelica Acutiloba Root is an old herbal medicine with a long history. Since ancient times, it has been used as a remedy for gynecological illness with chief complaints of hematogenous tonic, chills, menstrual irregularity, and anemia.
In recent years, several components have been elucidated as the ingredients of Angelica Acutiloba Root through research on pharmacology and natural product chemistry. It was found that the main component was believed to be a phthalide-type ligustilide. For ligustilide, sedative action, central depressant action, and psychotropic action were reported in pharmacological studies. Therefore, the author believes that Angelica Acutiloba Root could be used as an agent for mental and neurological disorders.
However, in former pharmacology journals there are no descriptions of ligustilide as a component of Angelica Acutiloba Root. Regarding ligustilide, in 1960, Mitsuhashi et al. isolated a new active ingredient of phthalides from the essential oil component of Hokkai Angelica. On the other hand, the first study on the ingredients of Angelica Acutiloba Root was conducted by Kariyone et al. in 1936, focusing on the essential oil
of a fruit with botanical origins from Angelica Acutiloba Root. Kariyone et al. proved that Ligusticumsaure lacton existed as the main aromatic ingredient in the essential oil of Angelica Acutiloba Root.
Therefore, this time the author researched the historical background of Angelica Acutiloba Root ingredients. He then examined the relationship between ligustilide and Ligusticumsaure lacton provided by Kariyone et al. As a result of this literary investigation, the author believes that the Ligusticumsaure lacton once reported by Kariyone et al. is a mixture of several phthalides including ligustilide.
