抄録
As an attempt to analyze the side-effects of antianxiety drugs in various psychological functions, 20 mg of medazepam, 6 mg of diazepam and inactive placebo (luctose) were orally administered to ten male and female student subjects (paid volunteers). The author's discussion was concerned with the effects of these drugs upon self-rating for sleepiness and emotional-somatic condition as well as upon visual and visual-motor functions.In the self-rating scale, the degrees of sleepiness (1 scale) and emotinoal-somatic condition (10 scales) of the subject were measured according to 7 degrees of rating.Eight visual tests were given : (1) flicker, (2) figure-groudnd reversal, (3) digits recognition, (4) reaction time, (5) time estimation, (6) visibility of Landolt's ring. (7) tri-dimensional appearances in plane figure and (8) figure tracing.According to the results obtained, no statistically significant differences on these self-ratings and visual tests were shown between the two drugs with the exception of their reaction time.On the self-rating of emotional-somatic condition, it was found that the subject tended to be calm and loose in his emotional state and dull in his somatic condition, after administration of medazepam and diazepam (but statistically not significant).Reaction time increased after administration of medazepam and decreased after administration of diazepam under this condition. An interesting fact was that, in diazepam condition reaction time decreased to 100 msec. or less in many subjects.At present we are investigating the effect of dasage variation on reaction time, temporal change after drug administration on it, and so forth.
