Endometrial lesion cytodiagnosis comparing the Masubuchi method and Honest Super Brush

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Objective : We compared the clinical utility of the brush method (Honest Super Brush) to the aspiration method (Masubuchi method).
Study Design : Between 2005 and 2007, 1099 endometrial cytology samples from 856 subjects were collected using aspiration and brush methods. Cytological examination results showed suspicious or positive findings in either or both methods compared to those of histological examinations.
Results : In the 1099 samples, the difference in the proportion of samples unsatisfactory for evaluation in the aspiration and brush methods was statistically significant at 15.6% versus 5.3% (p<0.01). Among 160 subjects with suspicious or positive results in either or both methods, 120 (75%) had endometrial cancer or associated lesions. The rate of suspicious or positive findings in the aspiration method was 94.2% (113/120) versus the brush method at 93.3% (112/120).
Conclusion : The diagnostic accuracy of the brush method appears equivalent to that of the aspiration method. The ratio of samples unsatisfactory for evaluation with the brush method was significantly lower, however, than for evaluation with the aspiration method. The brush method may therefore be advantageous when used as a tool for screening endometrial cancer.