日本臨床細胞学会雑誌
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
大腸癌細胞におけるMMP-7の発現とその臨床的意義
池田 聡木村 博本間 恵美子鈴木 恵子芝田 敏勝船越 尚哉
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2000 年 39 巻 6 号 p. 541-542

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To study the clinical significance of MMP-7 in colorectal cancers, we investigated 69 cases of imprint smear using immunocytochemistry and in situ hybridization. A total of 39 of 69 cases were positive for MMP-7 expression by immunocytochemistry. The expression of MMP-7 protein and mRNA were correlated. Positive cases of MMP-7 proteintented to be moderately differentiated tumors of the sigmoid colon or rectum, and invasive cases. The expression of MMP-7 and metastases to lymph nodes and liver were strongly correlated. In conclusion, MMP-7 may be a useful marker for invasion and metastasis in colorectal cancer.

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