In this article, I describe therapeutic exercise for disorders of higher brain function from the following points of view: developmental process of brain, alteration of brain function after physical therapy and brain fuction related to human activity. From the above points of view, 1) reduction of the compensatory motion, 2) location of the body axis, and 3) application of the search movement for physical therapy are thought to be important. Especially, we have to pay attention to search activity by patient at the scene of physical therapy treatment.