抄録
A thiamine regulatory mutant of Escherichia coli overproduced a compound which served to satisfy the nutritional requirement of Escherichia coli strain 70-17 for the pyrimidine moiety of thiamine. This compound was separated, purified, and identified as hydroxymethylpyrimidine on the basis of chromatographic, bioautographic and spectral data. In this mutant the synthesis of hydroxymethylpyrimidine was not controlled by thiamine or thiazole, but significantly inhibited by purines and some purine analogues.
Histidine reversed the inhibition of hydroxymethylpyrimidine synthesis by adenine.
