Ca代謝及び肺機能より見たる肺結核に対する珪肺の影響に関する臨床的並びに実験的研究

抄録

The influence of silicosis, alluminosis and titanosis on pulmonary tuberculosis was investigated by studies of calcium metabolism and pulmonary functions. The results of these studies led the author to the following conclusions. 1) Clinically, silicosis appears to have some adverse effects on pulmonary tuberculosis as revealed by pulmonary function studies. 2) The serum calcium level is higher in patients with pulmonary silicotuberculosis than in those with pulmonary tuberculosis. This might suggest that silicosis has a good effect on pulmonary tuberculosis. However, in the early stage of experimental pulmonary silico-tuberculosis the serum calcium level is lowered. Differences in these results are probably due to the different stages of the disease. If the experiments were performed at different stages, the results would perhaps be the same as in our human patients. 3) Animals with early experimental pneumoconiosis, including silicosis, show some differences in the calcium level, depending on the serum, the kind of the tissue, and the kind and the amount of the dust used. However, the addition of pulmonary tuberculosis to all types of pneumoconiosis affects calcium metabosism adversely. The addition of pneumocociosis to tuberculosis, however, does not always lower the calcium level. In general, either pneumoconiosis or pulmonary ruberculosis increases the abnormality in the calcium metabolism of the other. Histological examinations showed that the addition of pneumosoniosis to tuberculosis always cause pulmonary lesins to enlarge. However, the addition of tuberculosis to pneumoconiosis causes no change in the histological appearance. Thus, changes in the calcium level are not always related to tissue degeneration. 4) It is probable that some of the differences in the above results are due to differences in the methods used on experimental animals, and espesially to different stages of the disease. It is expected that further clinical and experimental studies on these topics will reveal interesting and important findings.