8-オキシカプリル酸およびその誘導体について

抄録

Methyl 8-oxycaprylate was prepared by means of Brown-Walker electrolytic oxidation of methyl hydrogen azelate. The free acid was separated from the product using maleic anhydride as a reagent. On the other hand, 8-oxycaprylic acid was prepared from methyl hydrogen azelate by the following method; the ester was transformed into the Ag salt, brominated, acetylated and hydrolized. As it was confirmed identical for the separated acid in comparison with the synthesized hydroxylic acid, the above electrolytic reaction was found as a new process for producing it.
For the acid, authors measured the solubility for water and benzene, the velocity of the formation of the polyester at different temperatures. Ethyl-, isopropyl-, isobutyl- and isoamyl 8-oxycaprylate were synthesized. These compounds are new derivatives of 8-oxycaprylic acid. By the trans-esterification of the monoglyceride of the acid, it was found that the dimeric lactone of 8-oxycaprylic acid was obtained.