ピラゾリジノン環を有する界面活性剤の合成と抗菌性

抄録

New cationic and amphoteric surfactants containing N-long alkylpyrazolidinone ring have been derived from alkylhydrazine. The antimicrobial activities of these surfactants were tested using Gram positive, Gram negative bacilli and fungi by Minimum Inhibition Concentration's method. The effects of the chain length of alkyl group in pyrazolidinone and also an introduction of propionic acid and acetic acid group into N-alkylpyrazolidinone were studied. Antimicrobial activities of these cationic surfactants, N-alkylpyrazolidinone, against microorganism were low or absent. But antimicrobial increasing effect of the introduction of acetic or propionic acid into the corresponding N-alkylpyrazolidinone was shown in some microorganisms. As for the alkyl group in N-alkylpyrazolidinone, dodecyl group was more potent than decyl group. And the N-alkylpyrazolidinoyl propionic acid was generally more active than the acetic acid derivative. Moreover, surface activities of aqueous solution of these surfactants were confirmed.