血清脂質
リポプロテインを中心に
1988 年 37 巻 10 号 p. 794-801
詳細
1988 年 37 巻 10 号 p. 794-801
The lipoproteins are globular particles which contain a non-polar core, triglyceride and cholesterol ester, surrounded by phospholipids, unesterified cholesterol and various apoproteins.
Dietary triglycerides and cholesterol are incorporated into chylomicron, which are eventually hydrolyzed into chylomicron remnants by lipoprotein lipase. Remnants enriched with B-48 and E are taken up by hepatic cells.
Endogenously synthesized triglyceride in the core of VLDL are secreted into the blood, subsequenly hydrolyzed into LDL, rich in cholesterol and B-100, via IDL. IDL and LDL are catabolized by the liver through LDL receptor.
HDL, produced either by the hydrolysis of chylomicron and VLDL, or synthesized directly by the liver and intestinal cells, transports free cholesterol of the cell to the liver by LCAT.
Various defects in apolipoproteins A- I, B, C- II and E are responsible for the development of hyper-lipoproteinemias, which are also produced by the abnormality by LDL receptor activity and lipid transfer protein.
