Studies on Coenzyme Q (Co Q) have been developed as an intrinsic factor in the mitochondrial respiratory chain. Among electron transfer members in the chain, Co Q is the sole lipid soluble substance and occupies a pivotal position. A mobile quinone model involving Q binding protiens is proposed to explain the topology of Co Q in mitochondrial membranes. HMG Co A reductase inhibitors were used to clarify the role of Co Q in cell biology.
When Co Q is administered at pharmacological doses, additional roles as a non-specific antioxidant and membrane stabilizer are considered. The incorporation of Co Q into tissues has been investigated in detail. Clinical applications, particularly in cardiac disorders, have been perfomed successfully.
