抗体による分子認識の光スイッチング
1994 年 43 巻 11 号 p. 933-940
詳細
1994 年 43 巻 11 号 p. 933-940
Monoclonal antibodies were raised against nonnatural amino acids carrying aromatic groups, such as pyrenyl group and trans-azobenzene group. The anti-pyrenyl antibody was used to investigate fluorescence behavior of pyrenyl groups bound to the antibody. The hapten was found to be bound not very tightly deep inside the binding site. The anti-azobenzene antibody was found to bind only the trans form of azobenzene group. By using this unique property, photoswitching of an enzyme reaction and photocontrol of the antibody binding to solid surfaces were demonstrated.
