脂質二分子膜中におけるリン脂質とスフィンゴ糖脂質との相互作用

抄録

Molecular Interactions between Phospholipids and Sphingoglycolipids in a Lipid Bilayer were investigated by measurements of the micropolarity, microviscosity, microfluidity, and surface charge density of the liposomes.
Liposome formation was dependent on the concentrations of sphingoglycolipids and/or their sugar chains. Liposomal bilayer membranes were stabilized by the addition of suitable amounts of sphingoglycolipids. The absolute value of surface charge density of liposomes decreased with an increase in the concentration of sphingoglycolipids. The stability of liposomes modified by sphingoglycolipids was depended both on the ceramide and sugar chain involved.