Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I

Naoya Ichimaru; Masato Abe; Atsushi Kenmochi; Takeshi Hamada; Takaaki Nishioka; Hideto Miyoshi

doi:10.1584/jpestics.29.127

Notes

Synthesis of ¹³C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I

Naoya Ichimaru, Masato Abe, Atsushi Kenmochi, Takeshi Hamada, Takaaki Nishioka, Hideto Miyoshi

著者情報

キーワード: mitochondrial complex I, acetogenin, ubiquinone

ジャーナルフリー

2004 年 29 巻 2 号 p. 127-129

DOI https://doi.org/10.1584/jpestics.29.127

詳細

抄録

Natural acetogenins are the most potent inhibitors of mitochondrial complex I. By synthesizing a ubiquinone-acetogenin hybrid inhibitor (named Q-acetogenin), we previously showed that a γ-lactone ring of acetogenins is completely substitutable with a ubiquinone ring. In this study, to open a new experimental approach to the study of acetogenin-complex I interaction, we report procedures for synthesizing ¹³C-labeled Q-acetogenins, wherein the carbonyl carbon at the 1- or 4-position of the ubiquinone ring is specifically ¹³C-labeled.

責任著者(Corresponding author)

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