Journal of Reproduction and Development
Online ISSN : 1348-4400
Print ISSN : 0916-8818
ISSN-L : 0916-8818
Review
The Role of Integrins in the Human Reproductive Process
Yasunori YOSHIMURA
著者情報
ジャーナル フリー

2002 年 48 巻 3 号 p. 215-232

詳細
抄録
Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangement, co-regulation of growth factor activities and activation of signal transduction. This review describes the available information regarding the role of integrins in human reproductive physiology and discusses their clinical implications. Integrins play important roles in several reproductive processes including fertilization, embryogenesis, and implantation. Disturbance of integrin expression in reproductive organs can be the cause, or the result of such reproductive disorders as endometriosis, unexplained infertility, hydrosalpinx, ectopic pregnancy, and preeclampsia. Further knowledge of the integrin-mediated regulation of cell growth and cell survival may facilitate our understanding of many key aspects of development and physiology in reproduction.
著者関連情報
© 2002 Society for Reproduction and Development

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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