抄録
Objective: The aim of the present study was to examine the association between the incidence of surgical site infection (SSI) and the duration of antimicrobial prophylaxis (AMP) and to analyze whether a short-duration AMP is appropriate for surgery in patients with rheumatoid arthritis (RA).
Methods: The clinical records of 508 patients with RA who underwent orthopedic surgery from 2004 to 2010 were retrospectively reviewed. The incidence of SSI in the short-duration group (AMP discontinued within 36 h after surgery) was compared with that in the long-duration group.
Results: SSI was recognized in 10 patients (2.0%). Although the incidence of SSI in the short-duration group (1.5%) was lower than that in the long-duration group (2.3%), the difference was not statistically significant (p = 0.8). There were also no significant differences in the incidence of SSI between different AMP agents (piperacillin, cefazolin, cefmetazole, and cefotiam).
Conclusion: The incidence rates of SSI did not differ between patients receiving AMP for a short or long duration. Our results were similar to those of previous studies on SSI in total joint arthroplasty mainly for osteoarthritis. Based on these findings, we recommend a short duration of AMP, even in patients with RA.
