抄録
At present, we report the study on basic features of tetracycline series antibiotics, available at preset, for photosensitive substances. NPRMTC, PRMTC, MINO, DOXY and OTC were potent in order of absorption spectrum and absorbance at 355nm in each TC series antibiotics. DOXY, PRMTC, OTC, NPRMTC and MINO_were potent in order of fluorescent intensity in third harmonic beam of Nd: YAG laser (355nm) and MINO hardly radiated fluorescence. The feature of each drug for absorption and wash out on domestic rabbit arteriol sclerosis site was studied with TC series antibiotics for intravenous injection. When arteriol sclerosis site vessel was observer with time, with wash out with PBS on 4 types of antibiotics, the fluorescent intensity ratio to normal site vessel was significantly high. Doxy>NPRMTC≅PRMTC≅OTC>MINO was shown in order of fluorescent intensity ratio, in change with time among each type or drugs.
