抄録
Experiments were carried out to investigate the effects of 3-aminopropanesulfonic acid (homotaurine, HT), administered alone or in combination with other drugs including hypotensive agents, on the blood pressure in rats with DCA-induced hypertension. The results obtained may be summarized as follows:
1) The oral administration of HT leads to a persistent lowering of the blood pressure in rats with DCA hypertension, producing maximal reductions in the blood pressure at 1 hour after administration with dosages not lower than 50 mg/kg. Both the degree and duration of the blood pressure fall increased proportionately with dosage increases.
2) Prolonged oral administration of HT to rats with DCA hypertension producedd consistently almost the same degrees of hypotension; hence no development of tolerance to the drug action.
3) HT was administered along with such hypotensive agents as hydralazine, fursemide and reserpine to dogs in order to determine whether and, if at all, to what extent the hypotensives might alter the effect of HT on the blood pressure. The concomitant administration. of these hypotensives did not significantly influence the effect of HT on the blood pressure.
4) In rats, pyridoxal phosphate administered in association with HT was observed to cause no conspicuous interference with the hypotensive effect of the latter.
