On-Chip Force Sensor for Mechanical Properties Measurement of Synechocystis sp. PCC 6803

抄録

Mechanosensitive (MS) channels on the cell membrane of Synechocystis sense the surface tension within the membrane caused by intracellular pressure. Therefore, we investigate the relationship between mechanical properties such as stiffness of the cell and its osmoadaption mechanism. In this paper we describe the design an on-chip force sensor which is able to measure reaction force of a single Synechocystis sp. PCC 6803 cell when it is compressed. We fabricate the robot integrated microfluidic chip including an on-chip sensor and an on-chip probe and evaluate the mechanical properties of single Synechocystis cell using this chip.