Bionic Synthesizerによる高弾性血管の誘導

抄録

We propose a fabrication method of artificial small blood vessel constructs via a layer-by-layer cellular assembly technique using smooth muscle cells, the construction of a biodegradable scaffold, and integration in a microfluidic perfusion culture system. Laminated cell layers form a tubular structure as the result of residual stresses imposed by the scaffold. After that, we can evaluate the elastic fiber development of the tubular structure with the mechanical stimulus utilizing the developed pulsatile perfusion culture system.