引張り刺激による培養細胞の伸び剛性の経時変化測定用デバイスの設計

抄録

We designed measuring device of temporal change in stiffness for cultured cell under stretching stimulus. To measure a small stiffness change, we proposed a method of integrating two strain sensors to culture substrate. In addition to use high sensitive rigid sensor like semiconductor strain gauge, we designed elastic substrate which has a structure to decrease a strain of sensor region. We designed an arch-shaped structure on the side of substrate for strain reduction. We confirmed an effect of the strain reduction by measuring sensor output against substrate strain using metal strain gauge. As a result, we showed that the sensor output is related to dimensions of arch leg.