抄録
Background: Following the introduction of highly active antiretroviral therapy (HAART), the prevalence of most opportunistic infection is declining. However, the beneficial effects of HAART on the occurrence of oral candidiase had not been entirely elucidated.
Methods: From August of 2003 to March 2004, we conducted a transversal study including 331 HIV-seropositive patients under HAART assisted in the University Hospital of Unicamp. Patients >18 years-old, without clinical evidence of oropharyngeal candidiasis and if they were undergoing a stable HAART regimen were enrolled. Specimens for fungal culture from oropharynx were collected by swab and oral Candida colonization was defined as the isolation of Candida spp. cultured in Sabouraud dextrose agar and CHROMagar. Identification to species was performed using API 20.
Results: Medium age was 38 years-old and 61.6% were male. One hundred and seven (44.4%) patients were colonized with Candida spp.. No difference was observed among patients receiving (171 patients) or not (132 patients) protease inhibitor (p=0.25). Median CD4 cell/mm, in colonizing and non colonizing patients, was 326 and 410 respectively (p=0.003) and viral load was undetectable in 59 out of 142 colonized patients and 114 out of 182 non colonized patients (p=0.0002). Mycological identification: C. albicans- 139; Candida non-albicans=22 (C. glabrata - 7; C.tropicalis -4; others-11).
Conclusions: the status of Candida carrier was associated with the number of CD4 cells and the viral load. The use of protease inhibitor did not influence the carriage of Candida spp.
