抄録
Newly weaned male rats were fed a riboflavin deficient diet for 5 weeks, and weights of the bodies and organs, riboflavin contents, and fatty acid composition of the lipids in the liver, kidney, heart and spleen were respectively determined in comparison with those of the controls.
The weight of the spleens of the deficient rats was less than that of the weaned rats, whereas the other organs were larger than each of the weanlings. The respective ratio of weights of the liver, kidney and heart to the body weight were larger than the controls in increasing order. Reduction in the quantities of riboflavin by the deficiency was the most in the liver, followed by the kidney, heart and spleen in decreasing order.
Fatty acid composition in total lipids of the rat organs was variably affected by the deficiency, but the ratio of arachidonic acid to total fatty acids decreased in all organs. The similar trend of decrease in the arachidonic acid was observed in phospholipids, and the reduction was the greatest in the spleen, followed by the liver, heart and kidney in decreasing order.
Fatty acid composition in total lipids in the serum was nearly the same as that of the liver, and was affected by the deficiency as well as in the liver. In the deficient rats, serum cholesterol and triglyceride decreased, but phospholipids and free fatty acids increased respectively in comparison with the controls. The serum protein tended to decrease in the deficient rats.
