Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
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Use of Herpesvirus Papio 2 as an Alternative Antigen in Immunoblotting Assay for B Virus Diagnosis
Seiichi TANAKAKazuaki MANNENHiroshi SATO
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2004 Volume 66 Issue 5 Pages 529-532

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Abstract

Herpesvirus papio 2 (HVP2), which infects baboons, is much more closely related genetically and antigenically to monkey B virus (BV) than to human herpes simplex virus 1(HSV1) and other related herpes viruses. The usefulness of HVP2 as an alternative test antigen in immunoblotting assays to detect BV-antibody in macaque monkey sera was assessed. Six HVP2 proteins reacted with BV-positive sera in immunoblotting. No specific bands could be detected with BV-negative sera. These results show the usefulness of HVP2 antigen as an alternative and safer antigen than authentic BV antigen in detecting BV antibody in immunoblotting.

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