Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Parasitology
Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities
Saw BAWMSaruda TIWANANTHAGORNKyaw San LINJunichi HIROTATakao IRIELat Lat HTUNNi Ni MAWTin Tin MYAINGNyunt PHAYSatoshi MIYAZAKITatsuya SAKURAIYuzaburo OKUHideyuki MATSUURAKen KATAKURA
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2010 Volume 72 Issue 4 Pages 525-528

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Abstract

Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of Trypanosoma evansi and cytotoxicity against MRC-5 cells in vitro. The methanol extract of dried rootbark of Vitis repens showed the highest antitrypanosomal activity with IC50 value of 8.6 ± 1.5 μg/ml and the highest selectivity index of 24.4. The extracts of Brucea javanica, Vitex arborea, Eucalyptus globulus and Jatropha podagrica had also remarkable activity with IC50 values and selectivity indices in the range of 27.2-52.6 μg/ml and 11.4-15.1 respectively.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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