Journal of Veterinary Medical Science
Online ISSN : 1347-7439
Print ISSN : 0916-7250
ISSN-L : 0916-7250
Virology
Phylogenetic analysis of canine distemper viruses isolated from vaccinated dogs in Wuhan
Wenke LICong CAIMingzhu XUEGuowei XUXiaoping WANGAnding ZHANGLi HAN
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ジャーナル フリー

2018 年 80 巻 11 号 p. 1688-1690

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Canine distemper virus (CDV) is an infectious agent that can cause canine distemper (CD), a lethal disease. Immunization is an effective method to control the infection; however, some cases of failed immunization are observed in animal hospitals every year. Therefore, in this study, we conducted phylogenetic analysis of the H gene of isolated CDVs. We first constructed a modified MDCK cell line, which constitutively expressed signaling lymphocyte activation molecule (SLAM), a specific receptor for CDV. The modified cell line was more suitable for propagation of CDV than the original MDCK cell line. Next, 9 CDVs were successfully isolated from 20 dogs with suspected CD-associated diseases. Of these CDV isolates, three were from vaccinated dogs. The analysis indicated that the H gene sequences of these 9 viruses were highly similar. The present study further supported the finding that the majority of CDV in China belonged to the genotype Asia-1, which was different from vaccine strains (America-1 and America-2). Although the clinical application of the vaccine suggested that it is effective against CDV infection, it remains an open question whether a novel vaccine based on the genotype of the Asia-1 strain would be more suitable for protection of dogs against Asia-1 CDVs infection.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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