Oral 5-aminolevulinic acid combined with sodium ferrous citrate prevents          blood–aqueous barrier breakdown after anterior chamber paracentesis in healthy beagle          dogs

Yuya OTAKA; Kazutaka KANAI; Aoi TOMATSU; Riyo SANGU; Daiki OKADA; Noriaki NAGAI; Yohei YAMASHITA; Yoichiro ICHIKAWA; Aki SAKAI; Kazuki TAJIMA

doi:10.1292/jvms.23-0347

Clinical Pathology

Oral 5-aminolevulinic acid combined with sodium ferrous citrate prevents blood–aqueous barrier breakdown after anterior chamber paracentesis in healthy beagle dogs

Yuya OTAKA, Kazutaka KANAI, Aoi TOMATSU, Riyo SANGU, Daiki OKADA, Noriaki NAGAI, Yohei YAMASHITA, Yoichiro ICHIKAWA, Aki SAKAI, Kazuki TAJIMA

Author information

Yuya OTAKA
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Kazutaka KANAI
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Aoi TOMATSU
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Riyo SANGU
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Daiki OKADA
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Noriaki NAGAI
Faculty of Pharmacy, Kindai University, Osaka, Japan
Yohei YAMASHITA
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Yoichiro ICHIKAWA
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan
Aki SAKAI
One Health Business Department, Companion Animal Group Neopharma Japan Co., Ltd., Tokyo, Japan
Kazuki TAJIMA
Department of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University, Aomori, Japan

Keywords: 5-aminolevulinic acid, anterior chamber paracentesis, blood–aqueous barrier, dog, sodium ferrous citrate

JOURNAL OPEN ACCESS

2023 Volume 85 Issue 12 Pages 1257-1260

DOI https://doi.org/10.1292/jvms.23-0347

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Abstract

This study investigated the preventive effect of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) on blood–aqueous barrier (BAB) breakdown induced after anterior chamber paracentesis (ACP) in beagles. 5-ALA/SFC (1/0.64 mg/kg or 3/1.92 mg/kg) or carprofen (4.0 mg/kg) was orally administered daily for 7 days prior to ACP. Then, a sample of the aqueous humor (AH) was collected from one eye via ACP (first sample) and again 60 min later (second sample). The protein and prostaglandin E2 (PGE2) concentrations in both samples were measured. Compared with the control group, high-dose 5-ALA/SFC and carprofen significantly reduced the AH protein and PGE2 concentrations in the second sample. Our findings suggest that 5-ALA/SFC suppresses BAB breakdown in dogs.

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