Safety Test and Field Study of an Oil-Adjuvanted H5N1 Avian Influenza Inactivated Vaccine

Takashi IMAMURA; Ryuichi SAKAMOTO; Takashi SASAKI; Norihide KOKUMAI; Toshiaki OHGITANI; Akira SAWATA; Zhifeng LIN; Masashi SAKAGUCHI

doi:10.1292/jvms.10-0091

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Safety Test and Field Study of an Oil-Adjuvanted H5N1 Avian Influenza Inactivated Vaccine

Takashi IMAMURA, Ryuichi SAKAMOTO, Takashi SASAKI, Norihide KOKUMAI, Toshiaki OHGITANI, Akira SAWATA, Zhifeng LIN, Masashi SAKAGUCHI

著者情報

キーワード: avian influenza, field trial, H5N1, safety test, vaccine

ジャーナルフリー早期公開

論文ID: 10-0091

DOI https://doi.org/10.1292/jvms.10-0091

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2010) , No. 11 p.1455

詳細

抄録

We previously reported the development of an inactivated oil-adjuvanted avian influenza vaccine using an apathogenic H5N1 strain of the same-lineage as the Eurasian lineage viruses currently epidemic in Asia. In this study, we confirmed the safety and evaluated the efficacy of this vaccine in layer chicken farms by field trials. No problematic adverse reactions occurred in the safety test. In addition, no adverse effects were observed in the field trial, and the antibody titer exceeded a protective level [hemagglutination inhibition (HI) antibody titer of 16] at 3 weeks after a single injection. Based on the above findings, this vaccine was confirmed to be safe and induced a protective level of antibody titer by single injection in farms.

責任著者(Corresponding author)

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